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OBJECTIVE：To evaluate the preventive effect of dexmedetomidine （DEX）on adverse drug reactions induced by carboprost tromethamine used in cesarean section ，and to provide evidence-based reference for rational drug use of cesarean section. METHODS：Retrieved from PubMed ，Cochrane library ，Embase，CNKI，CBM，Wanfang database and VIP during inception to June of 2019，randomized controlled trials about DEX （trial group ）versus normal saline （control group ）in the prevention of adverse drug reactions induced by carboprost tromethamine in cesarean section were collected. After data extraction of included literatures and quality evaluation with modified Jadad scale ，Meta-analysis was performed by using Rev Man 5.3 statistical software. RESULTS ：A total of 11 RCTs with 714 patients were included in this study. Results of Meta-analysis showed that the incidence of nausea [OR ＝0.09，95％CI（0.06，0.14），P＜0.000 01]，vomiting [OR ＝0.09，95％CI（0.05，0.15），P＜0.000 01]， facial flushing [OR ＝0.15，95％CI（0.10，0.22），P＜0.000 01]，chest distress [OR ＝0.12，95％CI（0.08，0.18），P＜0.000 01]， hypertension [OR ＝0.06，95％CI（0.04，0.11），P＜0.000 01] and tachycardia [OR ＝0.17，95％CI（0.12，0.25），P＜0.000 01] in trial group were significantly lower than control group ，with statistical significance. CONCLUSIONS ：DEX can reduce adverse drug reactions such as nausea and vomiting caused by carboprost tromethamine used in cesarean section.
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Objective@#To explore the application timing of carprostol tromethamine in the treatment of postpartum hemorrhage due to uterine atony, and to observe the clinical efficacy.@*Methods@#From January 2016 to June 2018, 62 patients with uterine atony and postpartum hemorrhage admitted to the Second People′s Hospital of Lianyungang were selected as study objects, and they were randomly divided into two groups according to the digital table, with 31 cases in each group.In the control group, after the delivery of the fetus, 20U of oxytocin was intravenously injected.If there was active hemorrhage on the dissection surface of the placenta, 40U of oxytocin was continued.If there was still hemorrhage, the uterus was injected with 250μg of carprostol tromethamine.In the observation group, after the delivery of the fetus, 20U of oxytocin was intravenously injected.If there was active hemorrhage on the dissection surface of the placenta, 250μg of carprostol tromethamine was injected immediately.If the patients in the two groups still had active bleeding in the uterus after the above treatments, the uterine cavity was filled with gauze or uterine artery ligation was performed to stop bleeding.The blood loss during the operation, 2h and 24h after surgery were recorded and compared between the two groups.The 24h postpartum hemoglobin(Hb) decreased value, treatment efficacy and the incidence of adverse reactions were also recorded and compared between the two groups.@*Results@#The intraoperative blood loss was (1 066.1±71.3)mL in the observation group, which was significantly lower than that in the control group [(1 163.6±70.9)mL], the difference was statistically significant(t=5.393, P<0.001). There were no statistically significant differences in 2h and 24h postoperative blood loss between the two groups (all P>0.05). The decrease of Hb in the observation group at 24h after birth was (20.80±6.25)g/L, which was lower than that in the control group [(26.90±9.21)g/L], and the difference was statistically significant(t=3.033, P<0.01). The treatment effective rate of the observation group was 87%(27/31), which of the control group was 77%(24/31), there were no statistically significant differences between the two groups(P>0.05).@*Conclusion@#Postpartum hemorrhage caused by uterine atony can be treated by early use of carprostol tromethamine, which can effectively reduce postpartum bleeding and promote the rehabilitation of patients.The curative effect is better than oxytocin, and it is worthy of clinical application.
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Objective To explore the application timing of carprostol tromethamine in the treatment of postpartum hemorrhage due to uterine atony ,and to observe the clinical efficacy.Methods From January 2016 to June 2018,62 patients with uterine atony and postpartum hemorrhage admitted to the Second People 's Hospital of Lianyungang were selected as study objects ,and they were randomly divided into two groups according to the digital table,with 31 cases in each group.In the control group,after the delivery of the fetus ,20U of oxytocin was intrave-nously injected.If there was active hemorrhage on the dissection surface of the placenta ,40U of oxytocin was contin-ued.If there was still hemorrhage,the uterus was injected with 250μg of carprostol tromethamine.In the observation group,after the delivery of the fetus ,20U of oxytocin was intravenously injected.If there was active hemorrhage on the dissection surface of the placenta ,250μg of carprostol tromethamine was injected immediately.If the patients in the two groups still had active bleeding in the uterus after the above treatments ,the uterine cavity was filled with gauze or uterine artery ligation was performed to stop bleeding.The blood loss during the operation ,2h and 24h after surgery were recorded and compared between the two groups.The 24h postpartum hemoglobin (Hb) decreased value,treatment efficacy and the incidence of adverse reactions were also recorded and compared between the two groups . Results The intraoperative blood loss was (1 066.1 ±71.3) mL in the observation group,which was significantly lower than that in the control group [(1 163.6 ±70.9) mL],the difference was statistically significant ( t＝5.393, P＜0.001).There were no statistically significant differences in 2h and 24h postoperative blood loss between the two groups (all P＞0.05).The decrease of Hb in the observation group at 24h after birth was (20.80 ±6.25)g／L,which was lower than that in the control group [(26.90 ±9.21) g／L],and the difference was statistically significant ( t＝ 3.033,P＜0.01).The treatment effective rate of the observation group was 87%(27／31),which of the control group was 77%( 24／31 ), there were no statistically significant differences between the two groups ( P ＞0.05 ). Conclusion Postpartum hemorrhage caused by uterine atony can be treated by early use of carprostol tromethamine , which can effectively reduce postpartum bleeding and promote the rehabilitation of patients .The curative effect is better than oxytocin,and it is worthy of clinical application.
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Objective To investigate whether BIS-guided (target-controlled infusion) propofol TCI can effectively prevent adverse effects of carboprost tromethamine in patients undergoing caesarean section.Methods Three hundred and fifty-four puerperants underwent spinal-epidural anesthesia were randomized into 3 groups:after fetal childbirth,in the control group,normal saline was infused at a rate of 10 ml/h.BIS 85 group,propofol with the initial target plasma concentrations of 0.8 μg/ml by TCI,adjusted TCI concentration and maintained BIS 80-90.BIS 75 group,propofol with the initial target plasma concentrations of 1.2 μg/ml by TCI,adjusted TCI concentration and maintained BIS 70-80,both until the end of operation.tThe rate of nausea,vomiting,diarrhea,chest congestion and headache were compared among 3 groups.Results Compared with the control group,the incidence of chest congestion was significantly reduced in BIS 85 group (P =0.004).The incidence of nausea,vomiting and chest congestion were significantly reduced in BIS 75 group (P ＜ 0.001,respectively).The puerperants in 2 BIS groups had no complaints of headache.Conclusion BIS-guided propofol TCI and maintaining BIS 70-80 can effectively prevent adverse effect of carboprost tromethamine in puerperants undergoing spinal-epidural anesthesia in caesarean section.
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Objective To compare the effect of dexmedetomidine combined with butorphanol to prevent the adverse effects of carboprost tromethamine druing cesarean delivery.Methods Ninety parturients with the risk factor of uterine atony,aged 24-40 years,weighting 55-85 kg,ASA physical status Ⅰ or Ⅱ,undergoing full term cesarean section,were randomly divided into dexmedetomidine combined with butorphanol group (group DB,n=30),butorphanol group (group B,n=30)and control group (group N,n=30).Three groups were intravenously injected corresponding drugs of carboprost tromethamine into uterus.Group DB was given intravenous injection dexmedetomidine 1 μg/kg combined with butorphanol 20 mg/kg.Group B was given butorphanol 20 mg/kg.Group N was given 0.9% sodium chloride solution.MAP,HR,and SpO2were recorded at different times,10 min after go into operation room (T0),10 min after carboprost tromethamine into uterus (T1),end of operation (T2).Ramsay sedation score was recorded at T1.The adverse effects of carboprost tromethamine were recorded.The initial time of lactation after operation was recorded.The initial time of lactation after operation,the height of uterine fundus at 1,3,5 d after operation,the oxyto-cin doses within 72 h after operation were recorded.Results Compared with group N,the MAP and HR of group DB and group B decreased obviously at T1(P<0.05),and group DB was lower than group B obviously at T1(P<0.05).Compared with group N,the scores of Ramsay in group DB and group B were significantly higher (P<0.05),group DB was higher than that of group B(P<0.05). Compared with group N,the incidence of nausea,vomiting,chest tightness,chest pain,hyperten-sion,tachycardia and chills in group B and group DB were significantly lower (P<0.05),and group DB was lower than that of group B (P<0.05).There were no significant differences of the initial time of lactation after operation,height of uterine fundus at 1,3,5 d after operation,the oxytoxin doses within 72 h after operation between the three groups.Conclusion Dexmedetomidine combined with butorphanol can effectively reduce the adverse effects of carboprost tromethamine druing cesarean delivery,the more stable hemodynamics and sedative effect,the effect is better than the sin-gle application of butorphanol,at the same time does not affect lactation,it is safe and effective for clinical use.
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Objective To investigate the clinical efficacy of carboprost tromethamine injection and misoprostol in high-risk of maternal postpartum. Methods 60 maternal with high-risk postpartum hemorrhage from January 2012 to January 2017 were divided into the control group and study group,30 case in each group.The two groups were treated with cesarean section surgery, the control group received misoprostol sublingual, study group were treated with carboprost tromethamine injection by intramuscular injection, recorded two groups of postpartum hemorrhage andthe incidence of adverse reactions. Results The study group of 2h postpartum hemorrhage, 24 h postpartum hemorrhage were significantly lower than control group (P<0.05); the incidence of adverse drug reactions in study group was 10.00%, and control group was 13.33%, there is no significant difference. Conclusion Carboprost tromethamine injection was effective and safe in the prevention of postpartum hemorrhage, which was beneficial to the quality of life and safety of high-risk postpartum women.
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Objective Onto observe the curative effect of carboprost tromethamine injection combined with mifepristone on the treatment of the patients with risky placenta previa. Methods 66 cases with placenta previa during mid pregnancy from January 2016 to December 2016 in Dingbian county people's hospital were randomly divided into two groups, 33 cases in the control group and 33 cases in the observation group. All patients were received cesarean section and traditional treatments such as oxytocin and gauze filling. Hemostatic effect, prognosis and incidence of adverse reactions in the two groups were compared. Results The intraoperative bleeding volume, the amount of vaginal bleeding 2 hours after operation and the amount of vaginal bleeding 2 to 24 hours after operation in the observation group were less than those in the control group (P<0.05). The rate of postpartum hemorrhage, the rate of disseminated intravascular coagulation and the incidence of puerperal disease in the observation group were significantly less than those in the control group (P<0.05). The sanguinous lochia time and menstrual recovery time in the observation group were better than those in the control group (P<0.05). There was no significant difference in the rate of hysterectomy and adverse reactions between the two groups. Conclusion Carboprost Tromethamine Injection combined with mifepristone in the treatment of pernicious placenta previa can effectively reduce the bleeding rate and promote the rehabilitation of pregnant women. It is safe and has no obvious adverse reactions. It is worthy of clinical application.
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Objective To investigate the clinical effect and the influence to coagulation factor of carboprost tromethamine on the treatment of the patients with postpartum hemorrhage. Methods 60 pregnant women with placenta previa complicated with postpartum hemorrhage from May 2016 to March 2017 were randomly divided into the control group (n=30) and the observation group (n=30). The control group were given oxytocin, the observation group were received carboprost tromethamine. Fibrinogen (FIB), prothrombin time (APTT), prothrombin time (PT) and platelet count before and after surgery in the two groups were analyzed by CA7000 automatic blood analyzer. The effect and coagulation indexes in the two groups were compared. Results The clinical curative rate in the observation group was 96.67% and 93.33% in the control group, the differences had no statistically significant. The amount of hemorrhage in postpartum 2h and 24h and the hemoglobin in postpartum 24h in the observation group were less than those in the control group (P<0.05); There was no significant difference about coagulation indexes between the 2 groups before treatment;The platelet count, PT and APTT levels in the observation group were lower than those in the control group, and the level of FIB was higher than that in the control group (P<0.05); The incidence of adverse reaction was 6.67% in the observation group and 10% in the control group, the difference was not statistically significant. Conclusion Choosing carboprost tromethamine to treat placenta prevail complicated with postpartum hemorrhage has a good curative effect, which is helpful to reduce the amount of postpartum hemorrhage and improve the coagulation indexes, so it is worth popularizing
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OBJECTIVE:To observe therapeutic efficacy and safety of Leonurus artemisia injection combined with carboprost tromethamine for preventing postpartum hemorrhage (PPH) of pregnant women after cesarean section. METHODS:177 pregnant women undergoing cesarean section were randomly divided into control group(87 cases)and observation group(90 cases). Preg-nant women of both groups received cesarean section. Control group was given intramuscular injection of oxytocin 20 U in uterine muscle wall above the incision after the foetus parturition,and given intravenous dripping of oxytocin 20 U added into 0.9% sodi-um chloride 250 mL;4 h after the operation,the pregnant women received intramuscular injection of oxytocin 10 U,every 12 hours,for 3 days. Observation group was given intramuscular injection of L. artemisia injection 2 mL and Carboprost tromethamine injection 1 mL in uterine incision after the foetus parturition;4 h after the operation,the pregnant women received intramuscular in-jection of L. artemisia injection 2 mL and Carboprost tromethamine injection 1 mL,and then give L. artemisia injectien 2 mL,ev-ery 12 hours,for 3 days. Clinical efficacies of 2 groups were observed as well as blood loss during operation,2 h after operation and 24 h after operation,the amount of hemoglobin(Hb)before operation and 24 h after operation,height of uterine fundus 3,7 d after operation,the occurrence of ADR. RESULTS:The total response rate of observation group was significantly higher than that of control group;blood loss during operation,2 h after operation and 24 h after operation,height of uterine fundus 3,7 d af-ter operation were also significantly than control group,with statistical significance(P0.05). 24 h after operation,Hb of pregnant women in control group was significantly lower than before operation and observation group,with statistical significance(P0.05). There was no statisti-cal significance in the incidence of ADR between 2 groups(P>0.05). CONCLUSIONS:L. artemisia injection combined with car-boprost tromethamine shows significant therapeutic efficacy for PPH of pregnant women underwent cesarean section,can signifi-cantly reduce intraoperative and postoperative blood loss,accelerates the recovery of uterus without increasing the rate of ADR.
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Objective To investigate the effect of carboprost tromethamine combined with oxytocin on postpartum hemorrhage of scarred uterus in late pregnancy, and to provide theoretical basis for the application of carboprost tromethamine combined with oxytocin. Methods From May 2015 to May 2017, 52 pregnant woman with postpartum hemorrhage with scarred uterus in late pregnancy in the sixth hospital in Beijing were divided into the control group and the observation group. The control group was treated with oxytocin, and the observed value was treated with progesterone tromethamine injection and oxytocin. Postpartum hemorrhage, the incidence of postpartum hemorrhage in the two groups were compared. Results The intraoperative blood loss, postoperative 2 h and postoperative 24 h bleeding in the observation group were significantly lower than those in the control group, the difference was statistically significant (P<0.05). The incidence of postpartum hemorrhage in the observation group was 3.85％, significantly lower than 11.54％ in the control group, the difference was statistically significant (P<0.05). Conclusion carboprost tromethamine combined with oxytocin in the treatment of postpartum hemorrhage in the pregnant woman with scarred uterus in late pregnancy is effective and can reduce the rate of postpartum hemorrhage and the amount of bleeding, so it is worthy of popularization and application.
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Objective To compare the clinical effect of different administration methods of carboprost tromethamine for the treatment of scar uterus with cesarean resection.Methods 120 cases of puerpera with uterine scar uterus and postpartum hemorrhage tendency were selected,and the history of cesarean section was once and more than once.According to the digital table,they were randomly divided into observation group(60 cases)and control group(60 cases),the observation group was divided into single carboprost tromethamine administration group(30 cases) and sub carboprost tromethamine administration group (30 cases).The clinical efficacy of the three groups were compared.Results In the observation group,the incidence rates of postpartum hemorrhage(13.33%,10.00%)were significantly lower than 28.33% in the control group(χ2 =10.844,6.822,all P 0.05).24h postpartum hemorrhage in the observation group[(263.11 ±137.04)mL,(359.98 ±212.35)mL]were significantly lower than those of the control group[(461.52 ±127.67)mL](t =5.795,2.247,all P 0.05).Conclusion Carbo-prost tromethamine can significantly reduce the bleeding rate of uterine scar again after cesarean section,sub carbo-prost tromethamine administration can significantly reduce the amount of bleeding in postoperative 24h,it is worth popularizing in clinical.
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Objective To investigate the clinical efficacy of carboprost tromethamine injection and misoprostol in high-risk of maternal postpartum. Methods 60 maternal with high-risk postpartum hemorrhage from January 2012 to January 2017 were divided into the control group and study group,30 case in each group.The two groups were treated with cesarean section surgery, the control group received misoprostol sublingual, study group were treated with carboprost tromethamine injection by intramuscular injection, recorded two groups of postpartum hemorrhage andthe incidence of adverse reactions. Results The study group of 2h postpartum hemorrhage, 24 h postpartum hemorrhage were significantly lower than control group (P<0.05); the incidence of adverse drug reactions in study group was 10.00%, and control group was 13.33%, there is no significant difference. Conclusion Carboprost tromethamine injection was effective and safe in the prevention of postpartum hemorrhage, which was beneficial to the quality of life and safety of high-risk postpartum women.
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Objective To explore the effect of carboprost tromethamine in high misk cesarean section for preventing and re-ducing postpartum hemorrhage and their side-effect .Methods 150 women underwent cesarean section with high-risk postpartum hemorrhage were randomly divided into three groups :group A (50 cases only using oxytocin) ,group B (50 cases only using carbo-prost tromethamine) and group C (50 cases using carboprost tromethamine and oxytocin) ,which were injected medicine immediate-ly after fetal disengagement .The blood loss (2 h and 24 h) ,hemoglobin ,hematocrit ,uterine contraction ,vital signs and extra treat-ment were compared among three groups .Results The amount of blood loss and the reduction of hemoglobin and hematocrit after the cesarean section in group B ,C were obviously lower than that of group A (P<0 .05) .In group B and C ,the rate of additional in-tervention was lower than group A .The incidence rate of side-effect in group B ,C was notably higher than that of group A (P<0 .01) .Conclusion Carboprost tromethamine injection in caesarean section can effectively decrease the loss of bleeding ,but the side-effect of carboprost tromethamine should be focus on .
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Objective To investigate clinical efficacy and safety of carboprost tromethamine injection combined with low B -Lynch suture for intractable postpartum hemorrhage placenta previa.Methods 125 cases of intractable postpartum hemorrhage placenta previa were divided into two groups according to treatment(n =62)with the observation group(n =63),the control group was administered oxytocin,and the line in the placental separation surface 8 interrupted suture;the observation group was used carboprost tromethamine injection combined with low B -Lynch suture.Clinical efficacy,blood loss,bleeding,postoperative bleeding 2h,24h after blood loss,transfusion rate and index sex hormone levels were compared before and after treatment.Results (1)After treatment,total effec-tive rate of the control group and observation group was 77.42%(48 /62)and 95.24%(60 /63)respectively.There was a statistically significant difference between the two groups(P 0.05),and after treatment,the index level differences were not statistically significant(P >0.05);(4)the two groups during treatment,liver and kidney functions were normal,three cases of the control group and two cases of the observation group occured nausea and vomiting.Conclusion Carboprost tromethamine injection combined with low B -Lynch suture has significant effect, a small amount of bleeding,high security for intractable postpartum hemorrhage placenta previa,which should be promoted.
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OBJECTIVE:To observe therapeutic efficacy and safety of carboprost tromethamine in the treatment of postpartum hemorrhage with two routes of administration. METHODS:285 patients with postpartum hemorrhage were randomly divided into control group(143 cases)and trial group(142 cases). Control group was given Carboprost tromethamine injection 250 μg on del-toid of arm;trial group was given same dose of Carboprost tromethamine injection via cervix uteri. Both groups received medicine after third stage of labor. The therapuetic efficacy,the amount of endometrorrhagia and colporrhagia within 2 h,the incidence of ADR after labor were observed in 2 groups. RESULTS:After treatment,the amount of postpartum hemorrhage was smaller than 400 ml in 2 groups and didn't exceed the standard,without statistical significance(P>0.05). The amount of endometrorrhagia in trial group was significantly higher than in control group,with statistical significance(P0.05). CONCLUSIONS:The intramuscular injection is selected for the prevention of postpartum hemorrhage caused by uterine inertia;the cervical injection is selected for the prevention of postpartum hemorrhage caused for the other patients.
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Objective To observe the curative effects of carboprost tromethamine injection in treatment of postpartum hemorrhage due to uterine inertia.Methods The clinical data of 118 patients with postpartum hemorrhage due to uterine inertia were analyzed retrospectively.The patients were divided into control group (68 cases) and observation group (50 cases) by treatment method.The patients in control group were given conventional treatment while the patients in observation group were given carboprost tromethamine injection on basis of conventional treatment.The postpartum blood loss after 2,24 h after treatment,the third labor time and therapeutic effects in two groups were recorded and compared.The patients in control group took carboprost tromethamine injection if conventional treatment did not work and all patients should have surgery immediately if repeatedly carboprost tromethamine injection were invalid; adverse reactions of using carboprost tromethamine injection were closely watched.Results The postpartum blood loss after 2,24 h after treatment in control group was (676 ± 86),(751 ± 70) ml,which was higher than that in observation group [(238 ± 62),(281 ± 56) ml],and there was significant difference (P ＜ 0.05).The third labor time in control group was (5.1 ± 1.9) h,which was longer than that in observation group [(2.1 ± 1.4) h],and there was significant difference(P＜ 0.05).After conventional treatment with 47 patients stopped bleeding in control group,and the effective rate was 69.1％ (47/58),while the effective rate in observation group was 96.0％ (48/50),and there was significant difference (P ＜ 0.05).Twenty-one patients in control group accepted carboprost tromethamine injection after treatment,while the traditional therapy did not work,and the effective rate increased to be 95.2％ (20/21).Among carboprost tromethamine injection treatment of 71 patients,2 cases' blood pressure increased,2 cases had facial blushing,1 case with mild headache,3 cases of diarrhea and 3 cases of nausea and vomiting (a total of 11 cases),and the incidence rate was 15.5％ (11/71),which was relatively minor.All patients were given symptomatic treatment and all rell eased within 24 h,and there were no other serious adverse reactions.Conclusion Using carboprost tromethamine injection to treat postpartum hemorrhage due to uterine inertia has more remarkable curative effects and higher clinical safety,which is worthy of clinical promotion.
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Objective To study the effect of oppressing with catheter balloon and carboprost tromethamine to prevent hemorrhage caused by central placenta previa during cesarean.Methods The clinical data of 22 cases oppressing with catheter balloon and carboprost tromethamine to prevent hemorrhage caused by central placenta previa during cesarean were analyzed retrospectively.Results Among of 22 cases,17 patients succeeded in haemostasis ＜ 2 000 ml.Catheter balloon was took out after 24 h.No infection and late postpartum hemorrhage.There were 3 uterine artery ligation because of placenta implantation with haemostasis 2 000-3 000 ml,1 uterine artery embolization,1 hysterectomy with haemostasis 4 000 ml because of disseminated intravascular coagulopathy and no maternal died.The patients were given postoperative routine antibiotics for 3-7 d,no infection and late postpartum hemorrhage.Conclusion Oppressing with catheter balloon and carboprost tromethamine is an effective measure to treat hemorrhage caused by central placenta previa during cesarean.
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Objective To investigate the carboprost ammonia butyl alcohol three plus motherwort injection on prevention of high risk maternal postpartum hemorrhage effect .Methods 120 cases of cesarean section operation and potential bleeding symptom of women were selected as the research object ,and randomly divided into two groups , the observation group of 60 cases using carboprost ammonia butyl alcohol three joint of leonurus heterophyllus injec -tion for prevention and treatment ,the control group of 60 cases used oxytocin for prevention and treatment ,prevention and treatment effects were compared between the two groups .Results After treatment,the observation group 2h,24h postpartum hemorrhage were (422.41 ±213.49)mL,(35.29 ±16.44)mL,were significantly less than those in the control group (589.64 ±345.21)mL,(69.31 ±29.47)mL(t=6.732,8.915,all P<0.05);the observation group 1 cases without production after bleeding ,control group 5 cases of postpartum hemorrhage ,statistically significant differ-ences between the two groups (χ2 =4.973,P<0.05).Conclusion Carboprost ammonia butyl alcohol three plus motherwort injection on prevention of high risk maternal postpartum hemorrhage has a significant effect ,which can re-duce the cesarean section uterine bleeding and reduce the amount of bleeding ,promote uterine involution ,conducive to maternal rehabilitation .
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Objective To discuss the curative effect of carboprost tromethamine in the treatment of uterine atony postpartum hemorrhage.Methods 50 cases of refractory uterine atony postpartum hemorrhage patients in cesarean section were divided into the observation group and the control group,each of 25 cases,the control group was given brace suture treatment,the observation group was given carboprost tromethamine base on the control group,curative effect,24h postpartum hemorrhage,hysterectomy,postoperative recovery and the effect of maternal lactation were compared between two groups.Results There showed no postoperative death,no infection,uterine necrosis,intestinal obstruction and other complications between two groups.Effective rate in the observation group was 85％,which was higher than 68％ in the control group (x2 =3.12,P ＜ 0.05).24h bleeding,uterine resection rate in the observation group were less than those in the control group (t =5.87,x2 =2.85,P ＜ 0.05).Puerperal morbidity between two groups was no statistical significance (P ＞ 0.05).the initial time of lactation,24h,48h lactation scores between two group were not significantly different (P ＞ 0.05).B ultrasound review in 6 weeks postpartum were normal.Conclusion Carboprost tromethamine in the treatment of refractory uterine atony postpartum hemorrhage is better,which can reduce the rate of hysterectomy significantly with safe,efficient,rapid and convenient.
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Objective To observe the effect of carboprost tromethamine(hemabate) combined with modified patch suture in placenta previa postpartum hemorrhage.Methods 62 patients with placenta previa were divided into the control group (3 0 cases) and treatment group (3 2 cases).The control group was treated with hemabate,and the treatment group was treated with hemabate combined with modified patch suture.The two groups of intraoperative,postpartum 2 hours,24 hours postpartum were compared in bleeding volume and hemoglobin changes.Results The intraoperative bleeding volume [(321.9 ± 67.8) ml vs (435.9 ± 83.3) ml] and 2h,24h postpartum bleeding volume [(417.7±68.0)ml vs (539.6 ±70.4)ml and (485.3 ±68.5)ml vs (621.0±81.3)ml]of the treatment group were significant less than that of the control group(t =5.926,6.938,7.133,all P ＜ 0.05).Significant difference in changes of hemoglobin level was also observed between the two groups,though postpartum level was not significantly reduced in the treatment group compared with the control group [(5.0 ± 6.5) g/L vs (-4.0 ± 6.8) g/L] (t =-3.662,P ＜ 0.05).Conclusion Hemabate combined with modified patch suture can be more effective in the prevention of postpartum haemorrhage in placenta previa.